Clinical Trial of the Week: Study of Chemotherapy With or Without Radiation Therapy for Patients with Non-Small Cell Lung Cancer

By Donna Loyle, communications specialist, LIMR

Researchers are recruiting patients who’ve been diagnosed with stage 4 non-small cell lung cancer (NSCLC) for a phase II/III randomized study. The goal is to discern if maintenance chemotherapy and stereotactic body radiation therapy (SBRT) together work better than maintenance chemotherapy alone in treating patients with stage 4 NSCLC.

Eligible patients must have already received 4 cycles of first-line/induction chemotherapy and experienced a partial response or are in stable condition. The complete list of inclusion/exclusion criteria is on the Main Line Health Clinical Trials website listed below.

Patients are randomized into two treatment arms. Those in Arm 1 receive maintenance chemotherapy. Those in Arm 2 receive SBRT plus maintenance chemotherapy.

Principal investigators for study NRG LU002, which is available at Lankenau Medical Center, are Albert DeNittis, MD, and Paul Gilman, MD. For more information, visit


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