Latest Clinical Research from LIMR

By Donna Loyle, communications manager, LIMR

 

Research studies with clinical implications for patients with COVID-19, triple negative breast cancer, aortic valve replacement, atrial fibrillation, lung cancer and chronic cough were published in peer-reviewed journals by investigators at the Lankenau Institute for Medical Research (LIMR) in December.

 

Vitamin A as potential anti-viral therapy, including coronavirus

Retinoic acid (RA; vitamin A) may be an effective prophylactic agent in minimizing airway barrier leak and as a potential therapy to prevent cellular leak caused by inflammation. The authors suggest that RA may be a useful adjuvant for anti-viral therapies, including COVID-19 treatments, as cytokine storms caused by inflammation are known to be related to morbidity.

LIMR investigators: James Mullin, PhD, and Sunil Thomas, PhD. The manuscript: “Retinoic acid improves baseline barrier function and attenuates TNF-α-induced barrier leak in human bronchial epithelial cell culture model, 16HBE 14o” in PLoS One.

 

Poorer outcomes seen in TNBC patients with metabolic syndrome

In this study of 177 Main Line Health patients diagnosed with triple negative breast cancer (TNBC) during the time period of 2007 to 2013, metabolic syndrome (obesity, diabetes, hypertension and dyslipidemia) was significantly associated with poorer outcomes. But overall survival was not impacted. The exception was among those TNBC patients with hypertension; these patients had both poorer disease-free and overall survival. “Hypertension management is therefore potentially an important aspect of the multidisciplinary care of the TNBC patient,” the authors noted. LIMR investigators: Kaitlyn Kennard, MD; Meghan Buckley; Sharon Larson, PhD; Ned Carp, MD; and Thomas Frazier, MD. The manuscript: “Metabolic syndrome: does this influence breast cancer outcomes in the triple-negative population?” in the journal Breast Cancer Research and Treatment.

 

Patient outcomes compared after aortic valve replacement

A retrospective review of 68 Lankenau patients who underwent transcatheter valve-in-valve implantation after bioprosthetic valve failure showed they had reduced need for permanent pacemakers, lower rates of atrial fibrillation and shorter hospital stays compared to patients who had minimally invasive reoperative aortic valve replacement. LIMR investigators: Serge Sicouri, MD; Meghan Buckley; and Scott Goldman, MD. The manuscript: “Transcatheter and ministernotomy aortic valve replacement after bioprosthetic valve failure” in Journal of Cardiac Surgery.

 

Biomarkers identified for stroke in afib patients

In patients with atrial fibrillation, the biomarkers most likely to be associated with subsequent ischemic stroke/systemic embolism represent fibrosis/remodeling; cardiac; vascular calcification; metabolism; and mucosal integrity/ischemia. LIMR investigator: Michael Ezekowitz. The manuscript: “Screening of Multiple Biomarkers Associated with Ischemic Stroke in Atrial Fibrillation” in Journal of the American Heart Association.

 

Optimal P-IDL in SBRT for lung cancer patients

The optimal prescription isodose line (P-IDL) range is 75%-80% for stereotactic body radiotherapy (SBRT) with volumetric-modulated arc therapy (VMAT) to treat early-stage lung cancers, according to a new retrospective study. The authors noted that applying optimized approaches can “significantly improve the lung sparing in SBRT VMAT plans with AXB dose calculation algorithm and makes treatment plans more conformal in high, intermediate and low dose regions, while higher dose is delivered to the target.” LIMR investigators: Albert DeNittis, MD; Tracey Evans, MD; and Thomas Meyer, MD. The manuscript: “Optimal prescription isodose line in SBRT for lung tumor treatment with volumetric-modulated arc therapy” in Journal of Radiosurgery and SBRT.

 

Laryngopharyngeal reflux may contribute to chronic cough

A retrospective chart review of 28 patients presenting with chronic cough found that laryngopharyngeal reflux may be a prevalent contributing or etiologic factor. After three months of reflux treatments, 60% reported improvement in cough. Among the possible contributing causes for non-responders were esophageal dysmotility, mycoplasma and pertussis.

LIMR investigator: Robert Sataloff, MD. The manuscript: “The Relationship Between Chronic Cough and Laryngopharyngeal Reflux” in Journal of Voice.

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