Latest Clinical Research from LIMR

By Donna Loyle, communications manager, LIMR


Research studies with clinical implications for COVID-19, breast cancer, tricuspid regurgitation, aortic surgery, atrial fibrillation, sternotomy and posterior glottic stenosis were published in peer-reviewed journals by investigators at and affiliated with the Lankenau Institute for Medical Research (LIMR) in January.


COVID-19 patients treated with tunneled dialysis catheters

Bedside tunneled dialysis catheters conserved resources, prevented transport-related complications and reduced personnel exposure among 36 COVID patients who were treated last spring at Lankenau Medical Center. LIMR investigator: Alexander Uribe, MD, and other LMC clinicians. The manuscript: “Bedside Tunneled Hemodialysis Catheter Placement in Patients with COVID-19” in Annals of Vascular Surgery.


Metabolic syndrome in breast cancer patients

In a retrospective review of 177 triple negative breast cancer patients (TNBC) treated from 2007 through 2013, metabolic syndrome was significantly associated with poorer outcomes, but overall survival was not impacted. Obesity was found to have a small potential benefit among TNBC patients. LIMR investigators: Kaitlyn Kennard, MD; Meghan Buckley; Sharon Larson, PhD; Ned Carp, MD; Thomas Frazier, MD, and other MLH clinicians. The manuscript: “Metabolic Syndrome: does this influence breast cancer outcomes in the triple-negative population?” in the journal Breast Cancer Research and Treatment.


Good results of Cardioband clinical trial

Results of a clinical device trial for patients diagnosed with tricuspid regurgitation (TR) showed high procedural feasibility with no 30-day mortality, a significant reduction of functional TR, and improvements in patient status. Main Line Health is participating in this early feasibility study that is testing the Edwards Cardioband™ tricuspid valve reconstruction system. LIMR investigator and MLH principal investigator for this trial: William Gray. The manuscript: “Early Feasibility Study of Cardioband Tricuspid System for Functional Tricuspid Regurgitation: 30-Day Outcomes” in JACC Cardiovascular Interventions.


Patient-reported outcomes after aortic surgery

Following minimally invasive aortic surgery, patient-reported scores for pain, depression and anxiety returned to preoperative levels or improved at one month, and even more so after three months. LIMR investigators: Serge Sicouri, MD, and Meghan Buckley. The manuscript: “Assessment of pain, anxiety and depression, and quality of life after minimally invasive aortic surgery” in Journal of Cardiac Surgery.


Detecting subclinical atrial fibrillation

Results of the REVEAL AF clinical trial, in which Main Line Health participated, showed that only heart palpitations were associated with subclinical atrial fibrillation (SCAF). No other prescreening symptoms that the researchers evaluated were associated with an increased likelihood of SCAF detection. LIMR investigator: Peter Kowey, MD. The manuscript: “Relation of Antecedent Symptoms to the Likelihood of Detecting Subclinical Atrial Fibrillation with Inserted Cardiac Monitors” in The American Journal of Cardiology.


Patient outcomes of mini- vs. full-Bentall procedures

Researchers compared outcomes of 97 consecutive patients who underwent upper ministernotomy Bentall procedures (mini-Bentall; 48 patients) to full sternotomy (full-Bentall; 49 patients) by a single Lankenau surgeon. They found that patients who underwent mini-Bentall required significantly less ventilation time and reoperations for bleeding vs. full-Bentall. No significant differences were seen in cardio bypass, aortic cross-clamp times, or ICU and hospital stay between the groups. LIMR investigators: Serge Sicouri, MD, and Meghan Buckley. The manuscript: “The mini-Bentall approach: a comparison to full sternotomy” in JTCVS Techniques.


Treatment for posterior glottic stenosis

A new, minimally invasive technique for the management of mild to moderate posterior glottic stenosis was introduced, along with a literature review and case study. “The two-stage procedure should reduce the risk of recurrence, but more experience is needed,” noted the authors. LIMR investigator: Robert Sataloff, MD. The manuscript: “A novel surgical technique for posterior glottic stenosis using a silastic implant” in Journal of Voice.

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